Scientist – Translational Medicine

Immunocore (NASDAQ: IMCR) is a pioneering, commercial-stage T cell receptor biotechnology company whose purpose is to develop and commercialize a new generation of transformative medicines which address unmet patient needs in oncology, infectious diseases and autoimmune disease. Our leaders in R&D are internationally recognised as some of the biotech industry’s most successful drug developers. We are creating not just an environment where great minds can interact but an innovation powerhouse answering the big questions.

Focused on delivering first-in-class biological therapies to patients, we have developed a highly innovative soluble TCR platform. Our ImmTAX molecules underpin a new generation of precision engineered drugs that harness the immune system to treat a broad spectrum of diseases with high unmet medical need, including oncology, infectious diseases and autoimmune diseases.

At Immunocore, we recognize that our employees are our greatest asset. We value the unique contributions each person brings to our team. By embracing Science, Trust, Respect, Integrity, Diversity, and Entrepreneurship (STRIDE), we create an environment where collaboration thrives, ideas flourish, and transformative changes happen. STRIDE represents more than just letters; it embodies our shared identity and drives our mission. We are dedicated to developing breakthrough therapies that transform patients’ lives, advancing medicine, and supporting one another in these pursuits.

Immunocore is proud to be an equal opportunity employer. As such, we are committed to fostering an inclusive workplace where everyone feels valued, respected, and empowered. We encourage applications from individuals of all backgrounds, regardless of race, color, religion, sex, sexual orientation, gender identity or expression, pregnancy, age, national origin, disability status, or any other characteristic protected by law.

The Translational Medicine Lab plays a pivotal role at Immunocore, generating biological data from both clinical trial and pre-clinical experimental samples to advance understanding of our platform and ultimately improve patients’ health. We are now looking for an enthusiastic Scientist to join our team. The successful candidate will design and conduct experiments to investigate the mechanism of action of our ImmTAX therapies and to test predictive hypotheses using pre-clinical models and patient derived samples.

Key Responsibilities:
• Design, conduct, and analyse experiments and record data in a timely manner following Company procedures.
• Keep abreast of technical advances in relevant fields through self-study and attending training sessions and conferences.
• Communicate results internally in lab meetings and seminars and externally in relevant conferences.
• Operate in accordance with the company’s health and safety policies
• Mentor other scientists by providing scientific advice and technical support.

Education, Experience and Knowledge:

Essential Qualifications:
• Knowledge of cancer biology, T cell biology and immunotherapies
• In depth experience in a range of cellular techniques and immunoassays:
• Molecular biology techniques, including generation and validation of stable overexpression (Lentiviral transduction) and CRISPR KO in cancer and/or T cells
• Experience with 3D (spheroid and organoid) culture models
• PBMC isolation and cell subset purifications
• T cell functional assays including cytokine release assays and killing assays
• Excellent oral and written communication skills
• Demonstrated ability to plan and work to agreed deadlines
• The ability to work both independently and as part of a team
• Demonstrated record of scientific accomplishments, including publications and presentations at conferences.

Desirable:
• Expertise in imaging by confocal microscopy and high throughput imaging systems
• Ex vivo analysis of tumour biopsies and tumour infiltrating lymphocytes
• Research experience with both solid and liquid tumour models
• Broad understanding of immunology spanning cancer immunotherapy, infectious diseases, and autoimmunity
• Experience in application of GCP principles to the analysis of clinical trial samples.